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KMID : 0854720100300010005
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Korean Journal of Asthma, Allergy and Clinical Immunology
2010 Volume.30 No. 1 p.5 ~ p.11
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Traffic-Related Air Pollution and Allergic Diseases
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Kim Hawn-Cheol
Leem Jong-Han
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Abstract
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The prevalence and incidence of allergic disease have increased during the last decade in most industrialized and developing countries in the world. Recent human and animal laboratory-based studies have proposed that persistent exposure to traffic-related pollution, especially particulate matter ＜10μg in diameter (PM10) from motor vehicles can enhance allergic inflammation and induce the development of allergic immune responses. In particular, the association between traffic-related pollution and asthma has been observed in many epidemiologic studies. Traffic- related pollution has been estimated by developing new indicators, such as the distance to main roads, road lengths within certain buffer, traffic counts, NO2 and PM10 concen-tration calculated by land use regression (LUR) model. Even though there still remain uncertainty and the data gap between traffic-related pollution and allergic rhinitis or atopic dermatitis, some studies have reported significant associations between them. Changes by traffic-related pollutants are regarded as biomolecular indicators for the susceptible population of asthma and other allergic diseases. Long-term studies, including environmental exposure in early life and gene-environment interactions, are needed to prevent and decrease the development of asthma and other allergic diseases.
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KEYWORD
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Air pollution, Traffic-related air pollutant, Asthma, Allergic rhinitis, Atopic dermatitis
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